Is it possible to have a presentation slide with only numbers? It is not very normal, but you can do it to create an interesting twist to your presentation. Show a slide that include a couple on numbers that mean something and can be linked to your presentation. Do not use too many numbers, because that will become too difficult to follow.
Have the numbers first shown in grey and then make a number get a colour and become bold for example when you start talking about the number. Link it all together. Use numbers that together make a nice story that you can tell and trigger the curiosity of your audience about what the next number will mean and links to your presentation. For example the first number is about the number of topics that you will cover during your presentation, the second number is a year that represents the start of the story, the third number is about the number of failed attempts to do something, the fourth number is about xyz, and the last number is 1, being the number one position that will be achieved when your audience will follow the sequence of the numbers as you explained in your presentation. So yes, it is possible to have just one slide with a couple of numbers to support your presentation.